- Role of urine osmolality as a predictor of the effectiveness of combined imipramine and desmopressin in the treatment of monosymptomatic nocturnal enuresis.
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Kwon Soo Lee, Jun Bo Chang, Jae Yoon Jang, Young Hwii Ko, Yong Hoon Park, Phil Hyun Song
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Yeungnam Univ J Med. 2015;32(2):85-89. Published online December 31, 2015
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DOI: https://doi.org/10.12701/yujm.2015.32.2.85
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- BACKGROUND
We examined the usefulness of urine osmolality, as a predictive factor in the treatment of monosymptomatic nocturnal enuresis (NE) with combination therapy of imipramine and desmopressin. METHODS: From May 2014 to April 2015, 59 monosymptomatic NE patients participated in this study. Early morning urine osmolality was measured at 1 week and 1 day before combination therapy of imipramine and desmopressin, and at 1 week and 2 weeks after therapy. The response to combination therapy was evaluated at 3 months after treatment. The mean period of combination therapy was 6.4+/-4.2 weeks. Therapeutic response was classified as complete (0-1 wet night/week), partial (over 50% reduction of night) and non-responders (less than 50% reduction of night). RESULTS: The cumulative rate of the complete and partial responders was 76.3%. Among the 3 groups, the statistically lowest value of pre-treatment urine osmolality was observed in the complete responder group (p<0.001). Urine osmolality increased in all groups after treatment, however, statistically the greatest difference between pre and post-treatment urine osmolality was observed in the complete responder group (p=0.024). No serious side effects were observed. CONCLUSION: Early morning urine osmolality and change of urine osmolality between pre and post-treatment have predictive values in the response to combined imipramine and desmopressin for treatment of monosymptomatic NE.
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Citations
Citations to this article as recorded by  - First-morning urine osmolality changes in children with nocturnal enuresis at the end of treatment
Yun ha Lee, Jae Min Chung, Sang Don Lee
Childhood Kidney Diseases.2024; 28(1): 27. CrossRef
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